Clenbuterol is a widely used bronchodilator. This drug is most commonly available in tablets of 20 mg, but can also be found in the form of a syrup or an injectable solution. Clenbuterol belongs to a large group of medicines known as sympathomimetic agents . These drugs affect the sympathetic nervous system in different ways, mainly through the distribution of adrenoceptors. In humans, there are nine different types of these receptors, which are named in accordance with the classification of the alpha or beta and t. D., Plus an appropriate number. Depending on the particular sensitivity of these materials to a variety of receptors, they can be successfully used for the treatment of diseases such as asthma, hypertension, heart failure, arrhythmia, migraine, and anaphylactic shock.
In the book, Goodman and Dzhillman “Pharmacological Basis of Therapeutics” (9th edition) is very well described by a variety of mechanisms of action of these drugs in the human body:
“In most cases, the action of catecholamines and sympathomimetic agents can be classified into seven types: 1) peripheral stimulating effect on certain kind of smooth muscle, such as vascular muscles, for example, that supply the skin, kidney, and mucous membranes, and the effects on cells of the salivary and sweat glands; 2) peripheral suppressive effect on another type of smooth muscle located in the walls of the intestines, bronchi and blood vessels supplying the skeletal muscles; 3) cardiac stimulating effect, which is to improve the speed and strength of the heart contractions; 4) a metabolic effect, namely the improvement rate of glycogenolysis in the liver and muscles and recovering the free fatty acids from adipose tissue; .. 5), endocrine effects, ie, the modulation of insulin, rennin, and pituitary hormones; 6) effects on the central nervous system: stimulation of respiration and, in conjunction with some drugs, increased activity during waking and psychomotor activity and decreased appetite; 7) presinapaticheskoe action that leads to a slowing or promotes the release of neurotransmitters, ie, the norepinephrine and.. acetylcholine. “
The drug is clenbuterol selective beta-2 sympathomimetic agent which acts primarily on only one of the three beta-receptor subtypes. An interesting fact is that this drug has a slight stimulating effect of beta-1.Due to the fact that beta-receptors 1tesno kardiodeystviem associated with clenbuterol, so that the drug reduces the reversible ventilation violation (and the action of beta-2 stimulation) and its side effects are less serious cardiovascular action compared to non-beta selected substances. Clinical study of the effect of the drug indicate that it is very effective bronchodilator which has almost no negative feedback patients.Also, the half-life of clenbuterol in the body long enough, and is about 34 hours. This facilitates the process to achieve the required level of drug in the body, ie. E. It is sufficient to take 1 or 2 times per day. All this makes it convenient for the reception of patients and they are easy to agree on his appointment. Despite the fact that clenbuterol is sold in many countries around the world, it has never been approved for use in the United States. Perhaps this is due to the fact that in the US there are a number of similar products for the treatment of asthma and the process of obtaining permission to trade in the drug in the United States will require a lot of time and expense in the firms concerned. Despite this, foreign production of clenbuterol can be easily found on the black market in the US.
During animal experiments, it was noted that clenbuterol shows anabolic effects, it would be very interesting for athletes. It is known that the drug is thermogenic agents and beta-2 act directly on fat cells and accelerate the breakdown of triglycerides to form free fatty acids. All this makes clenbuterol a very attractive for athletes, and to date it has always taken before a competition. Interested athletes often hope that this drug will contribute to the destruction of fat at the same time with an increase in strength and muscle mass. However, as reported in the Journal of “Medicine and Science in Sport and Physical Education” (August, 1995), the potential anabolic effect of clenbuterol is still open to question, research results are based on experiments with animals using much higher doses of medication than is needed for the bronchodilator. This information led to a great debate about whether or not anabolic clenbuterol. Some experts swear that the drug promotes muscle growth no matter what. For other research data is only proof that athletes are spending valuable time and money for a drug that does not profit them.
Such arguments continue today, as many athletes continue to use clenbuterol as a potent anabolic. In this case, the athletes bind and cycles dosage of the drug with what the result of two possible them to be reached and is transferred as a side effect. Perhaps manifestation of the following side effects of clenbuterol action, as well as other central nervous system stimulants, namely, hand tremors, insomnia, sweating, increased blood pressure and nausea ( “seasick”). Such disorders usually become less noticeable after a week or so after you start taking the drug once the patient gets used to it. Typically, during the cycle gradually increases dose medication every day to achieve the desired result. This reduces to a minimum the possibility of side effects of clenbuterol, which can be very serious if the start to take the drug in large quantities. More often than not men stop to 2-8 tablets a day, although there are also reports that a higher dosage as tolerated by the body. Women take fewer: 2-4 tablets daily. This drug is very rapidly increases the body temperature, but not very much, usually half a degree or so, sometimes a little more. This is due to the fact that your body has excess energy (largely from fat) and such a condition is not very nice.
To date, it is assumed that clenbuterol can be used depending on the purpose of the athlete. Obviously, the results of the drug receiving visible only for a limited period of time and then disappear gradually, mainly due to the reduction action of beta-receptors. If you are using clenbuterol to burn fat, this is the main purpose of the drug, it “works” in this direction for about 4-6 weeks. During this period it is necessary to monitor the temperature of the body, since clenbuterol is working by increasing the temperature. Once the temperature drops to normal, which means that the drug no longer acts as thermogenic agents. At this point, there is no need to increase the dosage, and to take a break in the reception of a few weeks in order to reach again the desired effect. If you are interested in improving muscle strength characteristics, then the effect of clenbuterol even smaller period of time – about 3-4 weeks. This is probably due to the lack of the anabolic effect as an increase in muscle strength while taking clenbuterol is most likely, with the stimulating properties of this drug (this is similar to the increase in power from taking ephedrine). However, all these issues remain controversial to this day.
Many athletes believe that the effect of “fat burning” of clenbuterol can be enhanced by taking additional medications. When combined with thyroid hormones, particularly potent Cytomel®, thermogenic effect can be very pronounced. This can help athletes to get rid of excess body fat in preparation for a competition, without reducing the number of calories in food. This combination of drugs may be used in the future during a steroid cycle to achieve relief of muscles. Such preparations for burning fat can significantly slow down the process of fat accumulation during the cycle, even if you are taking strong androgens aromatic. The combination of clenbuterol and thyroid hormone taken taken together with growth hormone to enhance thermogenic and anabolic effect of such therapy.
Counterfeits: You can easily buy real clenbuterol on the black market. “Street” price of 100 tablets is between $ 100-150 because of the high demand. Many European companies will send you clenbuterol at around $ 75 per pill, this figure looks more reasonable. Clenbuterol forged over the last time, but not as active as most other anabolic steroids. This clenbuterol is inexpensive and available on the black market so there is no need to produce a large amount of this product. Some unscrupulous manufacturers in the US to sell ephedrine or similar tablets with the label “clenbuterol”. Most likely, they were hoping that ephedrine will produce a similar stimulating effect and counterfeiting will not be noticed. Now you can find only a few fakes crudely made. If you know what you want to buy, then you will be easy to protect yourself from counterfeit. Clenbuterol is not produced in the United States, so avoid any products with “USA” lettering. It should only trust the drugs to the trade name of a foreign manufacturer. In most cases in the US occur Spiropent, Novegam and Oxyflux from Mexico and they can fly without fear. In Europe released the following well-known brands Spiropent, Broncoterol, Clenasma, Monores, Contraspasmin and Ventolase.You can also buy Bulgarian Clenbuterol, packaged in blisters (foil).